On 25 July 2013, Azmoun made his debut for the senior team in a UEFA Europa League match against Jagodina, coming on as a 73rd-minute substitute as Rubin won 1–0. On 29 August, he scored his first goal in just his second senior appearance for Rubin in a 3–0 Europa League win against Molde, coming on as a substitute in the 64th minute. He made his league debut with a goal and an assist on 6 October 2013, coming on as a substitute in the 72nd minute in a 5–1 win over Anzhi Makhachkala.